Figure 3. Cube (A) and
Cube-CS (B) images show
identical appearance of
a posterior horn medial
meniscus tear (small arrows)
and di;use full-thickness
cartilage loss on the medial
femoral condyle (large arrow).
Images courtesy of University of Wisconsin School of Medicine and Public Health.
provide a 30% reduction in scan time
for imaging the knee joint without a
decrease in SNR.4
“We did a preliminary study on 50
patients with knee pain and found no
di;erence in diagnostic performance
between Cube and Cube-CS—that
was encouraging. In most cases, there
was no appreciable di;erence in the
appearance of knee joint pathology
between the accelerated and non-accelerated images,” Dr. Kijowski says.
“While ARC parallel imaging decreases
SNR, Cube-CS did not.”
However, Dr. Kijowski and colleagues
reported increased blurring on Cube-CS images, especially when visualizing
low-contrast structures, which could
potentially decrease the conspicuity of
partial-thickness cartilage lesions and
subtle meniscus tears. While additional
larger clinical studies are needed
to compare Cube and Cube-CS for
detecting knee joint pathology, he
sees the potential to utilize CS to
reduce the scan time of current Cube
protocols or to acquire better quality
Cube images by allowing the use
of higher isotropic resolutions and
decreased echo train lengths without
an increase in scan time.
“We acquired 0.5 mm isotropic
resolution Cube-CS images with a 35
echo train length in a 5-6 minute scan,
which is something that could not be
done without the use of HyperSense,”
Dr. Kijowski says. “A single Cube-CS
acquisition could provide high-quality,
high-resolution multi-planar reformat
images for comprehensive knee joint
assessment and allow advanced
cartilage thickness analysis using 3D
segmentation software,” he adds.
The full results of Dr. Kijowski’s Cube-CS
study on the knee have been recently
published in the Journal of Magnetic
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2. Lustig et. al. “Sparse MRI: The Application of Compressed
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3. Reid SA, King KF, van der Wolf-de Lijster F, Graves MJ ,
Estko wski L , and Lomas DJ. Proc. Intl. Soc. Mag. Reson. Med
Navigated 3D MRCP with Compressed Sensing 23 (2015)
4. Liu F, Rosas H, Holmes J, King K, Peters R, Kijowski R. Rapid
Three-Dimensional Fast Spin-Echo Knee Imaging Using
Compressed Sensing. Proc. Intl. Soc. Mag. Reson. Med.
24 (2016). 1061.
5. Liu F, Rosas H, Samsonov A, King K, Peters R, Kijowski R.
Knee Imaging: Rapid Three-Dimensional Fast Spin-Echo
Using Compressed Sensing. J. Mag. Reson. Imaging.
Published online October, 2016.
Martin J. Graves, PhD, is Head of MR Physics and Radiology I T at Cambridge University Hospitals NHS Foundation Trust. He obtained his PhD from the
University of Cambridge and is a Fellow of the Institute of Physics and Engineering in Medicine and an Honorary Member of the Royal College of Radiologists.
The University of Cambridge is a collegiate public research university in Cambridge, England. Founded in 1209, Cambridge is the second-oldest university
in the English-speaking world and the world’s fourth-oldest surviving university.
Richard Kijowski, MD, is a Professor of Radiology and MSK radiologist at University of Wisconsin School of Medicine and Public Health. He received his MD
from Loyola University, Stritch School of Medicine; completed his residency at Oakwood Hospital and Medical Center in Dearborn, MI; and completed his
fellowship at Indiana University Hospital.
Founded in 1907, the University of Wisconsin School of Medicine and Public Health located in Madison, Wisconsin, is recognized as an international,
national and statewide leader in education, research and service. In 2005, the school transformed into the nation’s ;rst School of Medicine and Public Health,
integrating traditional medical school principles with public health policies and approaches.